Parametric Numerical Modeling and Fabrication of PCL Scaffolds for Bone Tissue Engineering Applications

Bone tissue engineering (BTE) is an interdisciplinary discipline that focuses on bone structure–function relationships for improving the replacement and/or regeneration of tissues. Thereby, architecture and load-bearing capacity embedded scaffolds play important role in generation artificial The aim this study was to develop a parametric numerical model accompanying fabrication polycaprolactone (PCL) BTE applications. Therefore, we manufactured layered PCL-based constructs using three-dimensional (3D) printing. material properties PCL were determined by mechanical testing, models based Beam188 Timoshenko elements developed software environment ANSYS. coated with collagen seeded osteoblasts, mesenchymal stem cells (MSCs), MLO-Y4 MG63 cell types. We demonstrated successful production 3D interconnected pores suitable Furthermore, provided first time geometrical behavior consisting compartments strains up 3%. structures allowed us flexibly new geometries silico, which its as tool supporting customized planning performing characterizations